Depends. If it's Seattle, sure. They could get a great exchange for Wilson and their picks would be low in every round. Chicage might as well, thinking Watson would make them a SB contender. Sound like a lot to give up, but low round picks don't have a great deal of value.
When it first started I was skeptical. The NL and AL played different styles of the game, and of course, the AL had the DH. That meant that strategies were different, more pitching changes in the NL since pitchers were often pulled for a pinch hitter and also double switches. Each league had their own set of umpires and it seemed the strike zones were also different for each league. NL umpires wore their chest protectors inside their jackets, while the AL umps used the exterior chest protectors they had to hold with one hand.
But, I did like the rivalries that were created with interleague play...Yankees-Mets, Cubs-White Sox and Dodgers-Angels. And, before the Astros moved to the AL, there was Rangers-Astros, too.
Now, it just seems normal, except for the DH rule, and I think it's worked out for the best.
If you want Latimore then that first round pick is gone plus you have to resign him. So between him and Lawson you pay probably around 25+mil per year combined. There goes majority of your cap so signing other guys will be slim pickings. Plus you now hope for a second round LT to start right away. Seems doubtful.