Aside from one game in 2008 (which I'll get to in a moment), the average margin of victory in 4 of the past 5 Bills/49ers games is 35 points! The combined scores of the winners winning is 166-26. Wow.
— Sal Capaccio 🏈 (@SalSports) December 1, 2020
2016: Bills 45-16
2012: 49ers 45-3
2004: Bills 41-7
2001: 49ers 35-0