Born: February 15, 1991 (age 27)
Height: 6 ft 0 in
Weight: 214 lb
NFL Draft:2013 / Round: 1 / Pick: 15
Vaccaro was drafted by the New Orleans Saints in the first round, with the 15th overall pick, of the 2013 NFL Draft. He was the first safety selected in the 2013 draft.
In the first game of the 2013 season, against the Saints' division rival, Atlanta Falcons, Vaccaro made a crucial play late in the game: he prevented an Atlanta touchdown by deflecting a fourth down pass away from tight end Tony Gonzalez, and into the hands of safety Roman Harper, securing the Saints' 23-17 win. In the 2013 season, Vaccaro played in 14 games making 79 tackles, 1 sack, 1 forced fumble, 1 interception, and 6 passes defended. Vaccaro's season was ended prematurely when he broke his ankle making a tackle against Carolina in week 15. He underwent surgery and was ruled out for the rest of the season. Fans voted him as the most impressive defensive rookie on the Saints' official website.
Vaccaro's play in 2014 was perceived as erratic; he made many big plays for the Saints, but he was implicated in many defensive errors, as the entire Saints defense played much less successfully than it had done in the 2013 season. One prominent website, Pro Football Focus, had Vaccaro rated 84th out of 86 safeties in the league. On December 9, early in Week 15 of the season, it was reported that head coach Sean Payton had decided that Vaccaro would be benched. However, in his December 11 press conference, Payton denied this, although leaving the door open for a change in Vaccaro's role.
Vaccaro bounced back in 2015 as he started every game and recorded 104 tackles. He played a big role in run support as he had many tackles along with a career-high three sacks. He was among the only bright spots on the porous defense of the Saints. Vaccaro had 13 tackles and a forced fumble against the Houston Texans in Week 11, along with 11 tackles in Week 5 against the Philadelphia Eagles.
On April 12, 2016, the Saints announced that the fifth-year option of Vaccaro's option would be picked up.
On November 10, 2016, it was reported that Vaccaro was facing a four-game suspension for violating the league's policy on performance-enhancing drugs for using Adderall and planned to appeal. He later dropped the appeal on December 9, 2016 and served the four-game suspension, keeping him out of the remainder of the 2016 season.[
He started 12 games in 2017 while dealing with a torn groin muscle, and later injured his wrist. He was placed on injured reserve on December 21, 2017 and underwent surgery on both injuries.